Poly (Lactic-Co-Glycolic) Acid (PLGA) Adjuvant for Immunotherapy

Nowadays, there are several efforts in immunotherapy especially biodegradable and biocompatible nano-polymers are using as immunomodulatory to induce cell mediated immune responses [1]. The advantages of nanoparticles have been proved to be potent immunomodulators in several kinds of vaccines to control a release of antigen, higher quality and quantity of immune responses and protect the integrity of antigens against degradation until delivered to the immune cell [1]. In particular, nanoparticle-based vaccines can demonstrate a critical role to CD8+ T-cell against viral infections by effective cross-present antigen MHC class I and MHC class II in pathways [1] Nanoparticles are potential carriers served as vaccine adjuvant for effective antigen delivery. Several materials of nanoparticles and liposomes have been proved to be safe and effective uses in modern vaccinology. Degradable polymers, for example polyesters (poly (lactic acid) and their copolymers), polyorthoesters, polyanhydrides and polycarbonates, are frequently used due to their properties are suitable for conjugation or loading with antigens, and can protect the antigen from degradation in vivo.